Sodium Carbonate → HCID 57668040, compound

Participants

Reaction Conditions

Reaction Steps

To N,N-dimethylacetamide 2.5 mL solution of methyl 4-bromo-2-(4-fluoroanilino)benzoate 70 mg were added 4-fluorophenylboronic acid 45 mg, sodium carbonate 57 mg and polymer-carried bis(acetato)triphenylphosphine palladium (II) 31 mg at room temperature, and it was stirred at 90° C. for 12 hours. After the reaction mixture was cooled to room temperature, insoluble matter was filtrated, and ethyl acetate and 1.0 mol/L hydrochloric acid were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after sequential washing with 1.0 mol/L hydrochloric acid and saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. 1.0 mol/L Sodium hydroxide aqueous solution 1.0 mL and ethanol 3.0 mL were added to the obtained residue, and it was stirred at room temperature for 1 hour. 6.0 mol/L Hydrochloric acid was added to the reaction mixture, solid matter was filtrated, and it was refined by silica gel column chromatography [Trikonex company, Flash Tube,2008, eluent; hexane:ethyl acetate:acetic acid=20:10:1] to give 2-(4-fluoroanilino)-4-(4-fluorophenyl)benzoic acid 7.8 mg of pale yellow solid.

Provenance & Evidence