Trifluoroacetic acid → HCID 57667918, compound

Participants

Reaction Steps

Trifluoroacetic acid 9.0 mL solution of tert-butyl 2-(4-fluoroanilino)-4-phenylbenzoate 0.44 g was stirred at room temperature for 1 hour. The solvent of reaction mixture was removed under reduced pressure, ethyl acetate and water were added to it, and it was adjusted to pH5.0 with saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and collected, and the solvent was removed under reduced pressure. Diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-phenylbenzoic acid 0.11 g of pale yellow solid.

Provenance & Evidence