Hydrochloric Acid → HCID 57668001, compound

Participants

Reaction Steps

6.0 mol/L Hydrochloric acid 2.0 mL was added to dioxane 2.0 mL solution of 4-benzoyl-2-(N-(4-fluorophenyl)acetamido)benzoic acid 0.39 g, and it was heated and refluxed for 2 hours and 30 minutes. After the reaction mixture was cooled to room temperature, 6.0 mol/L hydrochloric acid 1.0 mL was added to it, and it was heated and refluxed for 4 hours. After the reaction mixture was cooled to room temperature, the solvent was removed under reduced pressure, and ethyl acetate and 1.0 mol/L hydrochloric acid were added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; chloroform:methanol:acetic acid=20:1:1] to give 4-benzoyl-2-(4-fluoroanilino)benzoic acid 0.27 g of yellow solid.

Provenance & Evidence