Hydrochloric Acid → HCID 57668013, compound

Participants

Reaction Conditions

Reaction Steps

To N,N-dimethylformamide 0.9 mL solution of 2-iodo-4-phenoxybenzoic acid 45 mg were added 4-chloroaniline 27 mg, copper powder 5 mg and N-methylmorpholine 0.036 mL, and it was stirred under application of pressure at 180° C. for 15 minutes. After the reaction mixture was cooled to room temperature, 1.0 mol/L hydrochloric acid and ethyl acetate were added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure. The obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 65-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(4-chloroanilino)-4-phenoxybenzoic acid 9 mg of white solid.

Provenance & Evidence