Acetic Acid → HCID 57667927, compound

Participants

Reaction Steps

A suspension of hydrazine monohydrate 2.0 mL of 2-(N-benzylacetamido)-4-phenoxybenzoic acid 0.10 g was heated and refluxed for 3 hours. After the reaction mixture was cooled to room temperature, acetic acid 5.0 mL was added to it, and ethyl acetate and saturated sodium chloride aqueous solution were added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate:acetic acid=80:20:1] to give 2-(benzylamino)-4-phenoxybenzoic acid 20 mg of white solid.

Provenance & Evidence