Citric Acid → HCID 57667884, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of ethanol 3.0 mL of methyl 2-(4-fluoroanilino)-4-phenoxybenzoate 36 mg was added 10% sodium hydroxide aqueous solution 1.0 mL at room temperature, and it was stirred at 60° C. for 1 hour and 30 minutes. After the reaction mixture was cooled to room temperature,10% sodium hydroxide aqueous solution 1.0 mL was added, and it was heated and refluxed for 30 minutes. After the reaction mixture was cooled to room temperature,10% citric acid aqueous solution and ethyl acetate were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Diisopropyl ether and hexane were added to the obtained residue, and insoluble matter was filtrated. The solvent of filtrate was removed under reduced pressure, hexane was added to the residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-phenoxybenzoic acid 10 mg of white solid.

Provenance & Evidence