Hydrochloric Acid → HCID 57667913, compound

Participants

Reaction Conditions

Reaction Steps

To N,N-dimethylformamide 15 mL solution of 2-iodo-4-phenoxybenzoic acid 1.5 g, were added 2,4-difluoroaniline 0.67 mL, copper powder 0.084 g and N-methylmorpholine 1.2 mL, and it was stirred at 100° C. for 5 hours. After the reaction mixture was cooled to room temperature,1.0 mol/L hydrochloric acid and ethyl acetate were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=2:1] to give 2-(2,4-difluoroanilino)-4-phenoxybenzoic acid 0.60 g of white solid.

Provenance & Evidence