Hydrochloric Acid → 4-(Benzylthio)-2-(4-fluoroanilino)benzoic acid

Participants

Reaction Steps

10% Sodium hydroxide aqueous solution 1.0 mL was added to a suspension of 2-propanol 4.0 mL of methyl 4-(benzylthio)-2-(4-fluoroanilino)benzoate 0.36 g at room temperature, and it was heated and refluxed for 2 hours. After the reaction mixture was cooled to room temperature, 1.0 mol/L hydrochloric acid and ethyl acetate were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Diisopropyl ether and hexane were added to the obtained residue, solid matter was filtrated to give 4-(benzylthio)-2-(4-fluoroanilino)benzoic acid 0.30 g of white solid.

Provenance & Evidence