4-Fluoroiodobenzene → HCID 57667991, compound

Participants

Reaction Steps

To toluene 4.0 mL suspension of methyl 2-amino-4-(phenoxymethyl)benzoate hydrochloride 0.40 g, rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl 8 mg, palladium acetate 3 mg and cesium carbonate 0.89 g was added 1-fluoro-4-iodobenzene 0.47 mL, and it was heated and refluxed under nitrogen atmosphere for 16 hours. After the reaction mixture was cooled to room temperature, insoluble matter was filtrated, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=20:1] to give methyl 2-(4-fluoroanilino)-4-(phenoxymethyl)benzoate 0.22 g of pale yellow oil.

Provenance & Evidence