Hydrochloric Acid → 2-(4-Fluoroanilino)-4-(3-phenylpropyl)benzoic acid

Participants

Reaction Steps

10% Sodium hydroxide aqueous solution 0.2 mL was added to a suspension of ethanol 2.0 mL of methyl 2-(4-fluoroanilino)-4-(3-phenylpropyl)benzoate 0.10 g at room temperature, and it was heated and refluxed for 2 hours. After the reaction mixture was cooled to room temperature, 1.0 mol/L hydrochloric acid and ethyl acetate were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. Hexane was added to the obtained residue, and solid matter was filtrated to give 2-(4-fluoroanilino)-4-(3-phenylpropyl)benzoic acid 70 mg of white solid.

Provenance & Evidence