Methanol → HCID 57668048, compound

Participants

Reaction Steps

To a mixed solution of methanol 2 mL and tetrahydrofuran 2 mL of the obtained methyl 2-(4-fluoroanilino)-4-((E)-2-phenylvinyl)benzoate was added 2.0 mol/L sodium hydroxide aqueous solution 2.5 mL at room temperature, and it was stirred at room temperature for 4 hours. The solvent was removed under reduced pressure, water was added to it, and it was adjusted to pH4.0 with 1.0 mol/L hydrochloric acid. Solid matter was filtrated, and it was refined by silica gel column chromatography [eluent; hexane:ethyl acetate=2:1] to give 2-(4-fluoroanilino)-4-((E)-2-phenylvinyl)benzoic acid 58 mg.

Provenance & Evidence