Trifluoroacetic acid → 2-((1H-indol-5-yl)amino)-4-phenylbenzoic acid

Beteiligte Stoffe

Reaktionsschritte

Trifluoroacetic acid 5 mL solution of the obtained tert-butyl 2-((1-(tert-butoxycarbonyl)-1H-indol-5-yl)amino)-4-phenylbenzoate was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 50-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-((1H-indol-5-yl)amino)-4-phenylbenzoic acid 8 mg of yellow solid.

Herkunft & Nachweise