Trifluoroacetic acid → HCID 68957208, compound

Participants

Reaction Steps

Trifluoroacetic acid 3.0 mL solution of the obtained tert-butyl 2-((1-(tert-butoxycarbonyl)-1H-indol-5-yl)amino)-4-phenethylbenzoate was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-((1H-indol-5-yl)amino)-4-phenethylbenzoic acid 25 mg of pale yellow solid.

Provenance & Evidence