HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 219173Generated: October 26, 2026
tert-Butylsulfinamide, (R)-(+)- → (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide
https://huagongshe.com/reaction/219173
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| Reactant | 4-Bromo-2-chlorobenzaldehyde | HCID 14109109 | — |
| Catalyst | Copper Sulfate | HCID 24462 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide | HCID 57691068 | — |
Reaction Steps
A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08198448B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-afae97caf5a54d0fad555628d65671b3 |
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| Source note | uspto-grants-2012_06 |
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