Trifluoroacetic acid → HCID 57667933, compound

Participants

Reaction Steps

Trifluoroacetic acid 15 mL solution of obtained tert-butyl 2-(4-fluoroanilino)-4-((E)-2-(thiophen-3-yl)vinyl)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(4-fluoroanilino)-4-((E)-2-(thiophen-3-yl)vinyl)benzoic acid 9 mg of pale yellow solid.

Provenance & Evidence