Tert-butyl 2-(4-morpholinoanilino)-4-phenethylbenzoate → 2-(4-Morpholinoanilino)-4-phenethylbenzoic acid

Participants

Reaction Steps

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(4-morpholinoanilino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 45-80% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(4-morpholinoanilino)-4-phenethylbenzoic acid 11 mg of a white solid.

Provenance & Evidence