HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(4-Fluoroanilino)-4-(4-(hydroxymethyl)phenyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-(4-fluoroanilino)-4-(4-(hydroxymethyl)phenyl)benzoate | HCID 68962839 | — |
| Product | 2-(4-Fluoroanilino)-4-(4-(hydroxymethyl)phenyl)benzoic acid | HCID 57667838 | 3.6% |
Reaction Steps
Trifluoroacetic acid 5.0 mL solution of tert-butyl 2-(4-fluoroanilino)-4-(4-(hydroxymethyl)phenyl)benzoate 64 mg was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure,diisopropyl ether and hexane were added to the obtained residue, solid matter was filtrated to give 2-(4-fluoroanilino)-4-(4-(hydroxymethyl)phenyl)benzoic acid 2.0 mg of a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08327467B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-6f267ac85eae4d1a93828864b98b369d |
| Source note | uspto-grants-2012_12 |