HCID 68960002, compound → HCID 57668015, compound

Participants

Reaction Steps

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 2-(4-fluoroanilino)-4-(indolin-1-yl)benzoate, and it was stirred at room temperature for 2 hours and 10 minutes. The solvent was removed under reduced pressure, ethyl acetate and water were added to the obtained residue, and it was adjusted to pH6.5 with saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after sequential washing with water and saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. Diisopropyl ether was added to the obtained residue, solid matter was filtrated to give 2-(4-fluoroanilino)-4-(indolin-1-yl)benzoic acid 22 mg of a white solid.

Provenance & Evidence