Tetrahydrofuran → HCID 68962942, compound

Participants

Reaction Steps

To a mixed solution of tetrahydrofuran 10 mL and ethyl acetate 5.0 mL of tert-butyl 2-(4-fluoroanilino)-4-(2-nitroanilino)benzoate 0.35 g was added 10% palladium-carbon 74 mg, it was stirred under hydrogen atmosphere at room temperature for 4 hours and 30 minutes, and subsequently it was stirred at 34° C. for 4 hours. After the reaction mixture was cooled to room temperature, insoluble matter was filtrated, and the solvent was removed under reduced pressure. Hexane was added to the obtained residue, and solid matter was filtrated to give tert-butyl 4-((2-aminophenyl)amino)-2-(4-fluoroanilino)benzoate 0.15 g of a white solid.

Provenance & Evidence