HCID 68960442, compound → HCID 57667858, compound

Participants

Reaction Steps

Trifluoroacetic acid 10 mL solution of the obtained tert-butyl 2-(4-fluoroanilino)-4-((E)-2-(3-methylphenyl)vinyl)benzoate was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 2-(4-fluoroanilino)-4-((E)-2-(3-methylphenyl)vinyl)benzoic acid.

Provenance & Evidence