HCID 68957316, compound → HCID 68959410, compound

Participants

Reaction Steps

To the obtained tert-butyl 4-((E)-2-(4-(acetamido)phenyl)vinyl)-2-(4-fluoroanilino)benzoate were added acetic acid 2.0 mL,dioxane 2.0 mL and 10% palladium-carbon 30 mg sequentially, and it was stirred under hydrogen atmosphere at room temperature for 3 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated. Trifluoroacetic acid 10 mL was added to the obtained residue, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 4-(2-(4-(acetamido)phenyl)ethyl)-2-(4-fluoroanilino)benzoic acid 60 mg of a white solid.

Provenance & Evidence