HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-(2-(3,4-Dimethylphenyl)ethyl)-2-(4-fluoroanilino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-((E)-2-(3,4-dimethylphenyl)vinyl)-2-(4-fluoroanilino)benzoic acid | HCID 57668074 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-(3,4-Dimethylphenyl)ethyl)-2-(4-fluoroanilino)benzoic acid | HCID 57668020 | — |
Reaction Steps
To the obtained 4-((E)-2-(3,4-dimethylphenyl)vinyl)-2-(4-fluoroanilino)benzoic acid were added ethyl acetate 1.0 mL, methanol 1.0 mL and 10% palladium-carbon 10 mg sequentially, and it was stirred under hydrogen atmosphere at room temperature for 2 hours. The solvent was removed under reduced pressure after insoluble matter was filtrated to give 4-(2-(3,4-dimethylphenyl)ethyl)-2-(4-fluoroanilino)benzoic acid 2.5 mg of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08327467B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b1f9ac27d5804df9814009ce81a9f56c |
| Source note | uspto-grants-2012_12 |