Ethyl Acetate → HCID 57668087, compound

Participants

Reaction Steps

To the obtained tert-butyl 4-((E)-2-(3,4-dimethoxyphenyl)vinyl)-2-(4-fluoroanilino)benzoate were added ethyl acetate 1.5 mL, methanol 1.5 mL and 10% palladium-carbon 28 mg sequentially, and it was stirred under hydrogen atmosphere at room temperature for 3 hours and 30 minutes. The solvent was removed under reduced pressure after insoluble matter was filtrated. Trifluoroacetic acid 7.5 mL was added to the obtained residue, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, diisopropyl ether was added to obtained residue, and solid matter was filtrated to give 4-(2-(3,4-dimethoxyphenyl)ethyl)-2-(4-fluoroanilino)benzoic acid 56 mg of a yellow solid.

Provenance & Evidence