Trifluoroacetic acid → HCID 57667890, compound

Participants

Reaction Steps

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 4-(3-chlorophenyl)-2-((3-hydroxyphenyl)amino)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 80-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 4-(3-chlorophenyl)-2-((3-hydroxyphenyl)amino)benzoic acid 22 mg of a yellow solid.

Provenance & Evidence