HCID 68961745, compound → HCID 57667977, compound

Participants

Reaction Steps

Trifluoroacetic acid 10 mL was added to the obtained tert-butyl 4-(2-(2,3-dihydro[1,4]benzodioxin-6-yl)ethyl)-2-((3-hydroxyphenyl)amino)benzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, and the obtained residue was refined by reversed-phase silica gel column chromatography [eluent; 55-75% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to give 4-(2-(2,3-dihydro[1,4]benzodioxin-6-yl)ethyl)-2-((3-hydroxyphenyl)amino)benzoic acid 8.1 mg of a white solid.

Provenance & Evidence