Hydrochloric Acid → HCID 68962151, compound

Participants

Reaction Steps

To toluene 1.0 mL solution of 4-bromobiphenyl 0.12 g were added 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 4.8 mg, tert-butyl 2-amino-4-phenethylbenzoate 60 mg, cesium carbonate 0.13 g, palladium acetate 0.50 mg and tris(dibenzylideneacetone)dipalladium(0) 1.8 mg at room temperature, and it was heated and refluxed for 5 hours and 30 minutes. 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 4.8 mg, palladium acetate 0.50 mg and tris(dibenzylideneacetone)dipalladium(0) 1.8 mg were added to it, and it was heated and refluxed for 7 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 1.0 mol/L hydrochloric acid were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Fuji SILYSIA Chemical Ltd., PSQ100B(spherical type), eluent; hexane:ethyl acetate=200:1] to give tert-butyl 2-((biphenyl-4-yl)amino)-4-phenethylbenzoate 50 mg of a yellow oil.

Provenance & Evidence