Cesium carbonate → HCID 68958760, compound

Participants

Reaction Conditions

Reaction Steps

To 2-methyl-2-propanol 2.5 mL solution of tert-butyl 2-amino-4-phenylbenzoate 0.12 g were added cesium carbonate 0.29 g, N-(3-bromophenyl)acetamide 0.14 g, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 11 mg, tris(dibenzylideneacetone)dipalladium(0) 4.0 mg and palladium acetate 2.0 mg at room temperature, and it was stirred at 80° C. for 4 hours. Tris(dibenzylideneacetone)dipalladium(0) 4.0 mg, palladium acetate 2.0 mg and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 11 mg were added to it at room temperature, and it was stirred at 80° C. for 12 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and water were added to it. The organic layer was separated and collected,dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2008, eluent; hexane:ethyl acetate=2:1] to give tert-butyl 2-((3-(acetamido)phenyl)amino)-4-phenylbenzoate.

Provenance & Evidence