[(R)-1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine → 6'-[2-allyl-6-({4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2H-1,2'-bipyridin-2-one

Participants

Reaction Steps

The entitled compound was obtained as a yellow solid (35.5 mg) in the same manner as in Production Example 12-2, for which, however, (3R)-1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine was used in place of [5-amino-2-(4-methylpiperazin-1-yl)phenyl]methanol used in Production Example 12-2, and 6′-[2-allyl-6-(methylthio)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2H-1,2′-bipyridin-2-one was used in place of 2-allyl-6-(methylthio)-1-pyridin-2-yl-3H-pyrazolo[3,4-d]pyrimidin-3-one.

Provenance & Evidence