HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2191916Generated: November 3, 2026
Trifluoroacetic acid → N-methoxy-N-methylpiperidine-4-carboxamide
https://huagongshe.com/reaction/2191916
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate | HCID 11065582 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-methoxy-N-methylpiperidine-4-carboxamide | HCID 22405751 | 127.6% |
Reaction Steps
To a solution of tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (50 g, 182 mmol) in DCM (400 mL) was added trifluoroacetic acid (150 mL) and the resulting mixture was stirred for 6 h at 25-30° C. After completion of the reaction, the solvent was removed under reduced pressure to afford 40 g of N-methoxy-N-methylpiperidine-4-carboxamide product. [M+1]=173.04
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08329700B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-83ff458b2c7348b4929c43489d2431f6 |
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| Source note | uspto-grants-2012_12 |
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