Ethyl orthoformate → 5-Fluorobenzimidazole

Participants

Reaction Conditions

Reaction Steps

To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.

Provenance & Evidence