Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(Benzo[d]thiazol-2-ylamino)phenol | HCID 59326813 | — |
| Reactant | 4-(3-Chloropyrazin-2-YL)tetrahydro-2H-pyran-4-carbonitrile | HCID 59351305 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 59351203 | HCID 59351203 | — |
Reaction Steps
To a solution of 4-(benzo[d]thiazol-2-ylamino)phenol (0.097 g, 0.402 mmol) and 4-(3-chloropyrazin-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.09 g, 0.402 mmol) in DMSO (1 mL) was added cesium carbonate (0.262 g, 0.805 mmol). The resulting mixture was heated to 60° C. overnight. Purification by Biotage (0-100% EtOAc/hexane) provided product. MS (ESI, pos. ion) m/z: 430.0 (M+1). IC50 (uM) +++++.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329700B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-2efc3019844a4c34a5afebd987aa2b07 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
