Sodium Hydroxide → HCID 59740987, compound

Participants

Reaction Steps

3 ml of a 1N sodium hydroxide solution are added to a solution of 90 mg (0.23 mmol) of N-{4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluorophenyl}-2,2,2-trifluoroacetamide in ethanol (5 ml). The reaction is stirred overnight. The solution is extracted with tert-butyl methyl ether (two times 10 ml). The combined organic phases are washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. This gives a solid which is not purified any further.

Provenance & Evidence