Acetic Anhydride → HCID 59741011, compound

Participants

Reaction Conditions

Reaction Steps

3.02 g (7.60 mmol) of 3-fluoro-4-({1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)aniline are dissolved in 30 ml of acetic anhydride and stirred at 50° C. for one hour. Volatile components are then removed under reduced pressure and excess reagent is repeatedly removed azeotropically using toluene. The crude product is purified on a silica gel column (mobile phase: cyclohexane/ethyl acetate 1:1).

Provenance & Evidence