反应详情

温度

90 °C

192 mg (0.40 mmol) of N-[4-({3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]-pyridin-4-yl}oxy)-3-fluorophenyl]acetamide are dissolved in 7 ml of ethanol. 3.5 ml of 20% strength aqueous sodium hydroxide solution are added, and the reaction mixture is stirred at 90° C. overnight. The reaction mixture is partitioned between ethyl acetate and water. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate, and the solvent is removed under reduced pressure. The crude product is reacted without further purification.

1. customThe reaction mixture is partitioned between ethyl acetate and water
2. extractionThe aqueous phase is extracted with ethyl acetate
3. dry with materialThe combined organic phases are dried over sodium sulfate
4. customthe solvent is removed under reduced pressure
5. customThe crude product is reacted without further purification