N-[3-Fluoro-4-({1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]acetamide → N-[4-({3-Ethyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]acetamide

Participants

Reaction Steps

82 mg (0.18 mmol) of N-[3-fluoro-4-({1-[(4-methylphenyl)sulfonyl]-3-vinyl-1H-pyrrolo[2,3-b]-pyridin-4-yl}oxy)phenyl]acetamide are dissolved in 25 ml of ethanol. 19 mg (0.02 mmol) of 10% palladium-on-carbon are added, and the mixture is hydrogenated under a hydrogen atmosphere of 1.5 atm overnight. The mixture is then filtered through Celite® and the solvent is removed under reduced pressure. The product is reacted further without further purification.

Provenance & Evidence