反应详情

温度

90 °C

50 mg (0.11 mml) of N-[4-({3-ethyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]acetamide are dissolved in 3 ml of ethanol. 1 ml of 1N aqueous sodium hydroxide solution is added, and the mixture is stirred at 90° C. overnight. The reaction solution is partitioned between ethyl acetate and saturated sodium bicarbonate solution. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over magnesium sulfate and concentrated. The crude product obtained is reacted without further purification.

1. customThe reaction solution is partitioned between ethyl acetate and saturated sodium bicarbonate solution
2. extractionThe aqueous phase is extracted with ethyl acetate
3. dry with materialThe combined organic phases are dried over magnesium sulfate
4. concentrationconcentrated