Sodium Hydroxide → HCID 59740991, compound

Participants

Reaction Conditions

Reaction Steps

30 mg (0.065 mmol) of N-[4-({3-cyano-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]acetamide are dissolved in a mixture of 3 ml of ethanol and 3 ml of THF. 1.5 ml of 20% strength aqueous sodium hydroxide solution are added, and the mixture is heated at 90° C. overnight. Another 1 ml of 20% strength-aqueous sodium hydroxide solution is then added, and a further ml after 6 hours. The mixture is again stirred overnight. The reaction mixture is then partitioned between ethyl acetate and water. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure. The crude product is reacted without further purification.

Provenance & Evidence