反应详情

温度

90 °C

624 mg (1.25 mmol) of N-[4-({3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]-pyridin-4-yl}oxy)-3,5-difluorophenyl]acetamide are dissolved in 17 ml of ethanol. 10 ml of semiconcentrated aqueous sodium hydroxide solution are added, and the reaction mixture is stirred at 90° C. for 15 h. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is washed twice with water, dried over sodium sulfate and concentrated under reduced pressure. This gives a crystalline residue.

1. customThe reaction mixture is partitioned between ethyl acetate and water
2. washThe organic phase is washed twice with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThis gives a crystalline residue