Hydrochloric Acid → HCID 59741003, compound

Participants

Reaction Steps

A solution of 201 mg of N-{4-[(3-bromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluorophenyl}-2,2,2-trifluoroacetamide (280 μmol) in 4.00 ml of a mixture of hydrogen chloride in dioxane (4N) is stirred at RT overnight, and the precipitated crystals are filtered off and washed with diethyl ether. The solid residue (131 mg) is dissolved in 20 ml of THF. 2.7 ml of a 5% strength solution of lithium hydroxide in water (5.62 mmol) are then added, and the mixture is stirred at RT for 60 h. The reaction mixture is diluted with water and extracted twice with ethyl acetate. After drying over magnesium sulfate, the combined organic phases are concentrated and the residue is purified by preparative HPLC.

Provenance & Evidence