HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 11682690, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Reactant | HCID 59740991 | HCID 59740991 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 11682690 | HCID 11682690 | — |
Reaction Steps
49.0 mg (0.18 mmol) of 4-(4-amino-2-fluorophenoxy)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile and 33.0 mg (0.20 mmol) of 4,6-dichloropyrimidine-2-amine are suspended in 5 ml of water. 0.12 ml (0.24 mmol) of 2N hydrochloric acid is added, and the mixture is heated at reflux overnight. Using concentrated aqueous sodium hydroxide solution, the mixture is made alkaline, and the product is purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329716B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1d72a085f29f4a488ec8820a56b64d11 |
| Source note | uspto-grants-2012_12 |