Hydrochloric Acid → HCID 11595659, compound

Participants

Reaction Steps

200 mg (0.66 mmol) of 4-(4-amino-2-fluorophenoxy)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile and 104 mg (0.72 mmol) of 4-chloropyrimidine-2-amine are suspended in 9 ml of water and 4.5 ml of ethanol. 0.33 ml (1.31 mmol) of 4N hydrochloric acid is added, and the mixture is heated at reflux for 2 h. The mixture is made alkaline using concentrated aqueous sodium hydroxide solution, diluted with water and extracted with ethyl acetate. The organic phase is separated off and concentrated. The crude product is purified by preparative HPLC. This gives the title compound as crystals.

Provenance & Evidence