Hydrochloric Acid → HCID 11552830, compound

Participants

Reaction Steps

200 mg (0.67 mmol) of 3,5-difluoro-4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline and 88 mg (0.67 mmol) of 4-chloropyrimidine-2-amine are suspended in 6 ml of water/ethanol 1:1. 69 μl (0.81 mmol) of 37% strength hydrochloric acid are added, and the mixture is heated at reflux for 3 h. Using 1N aqueous sodium hydroxide solution, the pH is adjusted to 7, and the mixture is extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate and concentrated. The residue is purified by preparative HPLC.

Provenance & Evidence