Potassium Carbonate → HCID 67459801, compound

Participants

Reaction Steps

0.2 g (0.96 mmol) of 4-amino-5-bromo-2-chloropyrimidine, 0.196 g (1.15 mmol) of (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine and 0.399 g of potassium carbonate are heated in 1.5 ml of N,N-dimethylacetamide at 170° C. in a closed cell in a microwave for 60 minutes (Biotage initiator, http://www.biotage.com/DynPage.aspx?id=22001). The resulting crude mixture is absorbed on silica gel and purified by means of column chromatography using heptane/ethyl acetate as eluent. Following concentration by evaporation, 0.13 g of 5-bromo-N2-[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]pyrimidine-2,4-diamine is obtained (yield 37% at 95% purity).

Provenance & Evidence