Potassium Hydroxide → HCID 86643045, compound

Participants

Reaction Conditions

Reaction Steps

0.427 g of potassium hydroxide is added to a mixture of 0.47 g (1.34 mmol) of N2-[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]-5-[(trimethylsilyl)ethynyl]pyrimidine-2,4-diamine (Ex.: 1.98) in 3 ml of methanol and 1 ml of water, the mixture is stirred for one hour at 25° C., concentrated by evaporation and taken up in water. Then, extraction is carried out with ethyl acetate, and the organic phase is dried and concentrated by evaporation. Following purification of the crude mixture by column-chromatographic separation, 0.139 g of N2-[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]-5-ethynylpyrimidine-2,4-diamine is obtained (yield 33% at 90% purity).

Provenance & Evidence