참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline | HCID 13219441 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4,4-Dimethyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 57423310 | — |
반응 단계
1b (0.762 g, 4.73 mmol), ortho-fluoronitrobenzene (0.88 g, 5.67 mmol, 1.19 eq), and 2,4,6-collidine (0.66 mL, 1.05 eq) were pre-stirred 40s in a conical microwave container. It was then heated with stirring at a Personal Chemistry Microwave reactor with normal absorption at 250° C. for 1 h. The crude mixture was dissolved in CHCl3, and was purified by flash chromatography (hexanes/EtOAc) to give 0.66 g of crude 1c. LC-MS ESI 283 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08329718B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_12 |
|---|
| ORD ID | ord-640ac6380ff74ab887d48de1c51e3238 |
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| 출처 메모 | uspto-grants-2012_12 |
|---|
