HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2192221Generated: November 2, 2026
Sodium Hydroxide → N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea
https://huagongshe.com/reaction/2192221
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Benzoyl-3-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea | HCID 59337723 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea | HCID 59337709 | 80% |
Reaction Steps
To a solution of 2f (60 mg, 0.149 mmol) in MeOH was added 1N NaOH (0.2 mL, 0.2 mmol). The reaction mixture was stirred at 50° C. for 2 h. The solvent was evaporated under reduced pressure and co-evaporated with toluene to afford 2g (35 mg, 80%). MS (ES) m/z 298 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08329718B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-4f5eefab415a40a694667868a81fff5a |
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| Source note | uspto-grants-2012_12 |
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