反应详情

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 1e) (70 mg) and 2-bromo-N-(6-methylpyrazin-2-yl) acetamide (Example 2a) (49.2 mg) were dissolved in acetonitrile (1 mL) and left to stand overnight. Crystals separated on standing and were filtered and washed with acetonitrile (2×1 mL), ethyl acetate (2×3 mL) and diethyl ether (2×3 mL) and dried to yield the titled compound (24 mg).

1. waitleft
2. customCrystals separated on standing
3. filtrationwere filtered
4. washwashed with acetonitrile (2×1 mL), ethyl acetate (2×3 mL) and diethyl ether (2×3 mL)
5. customdried