HCID 58348350, compound → HCID 58348374, compound

HRID 2192323Notes

Reaction equation

HRID 2192323 reaction equation
[CH3:1][O:2][C:3]([C:5]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[CH2:11][CH2:10][CH:9]=[CH:8][CH2:7][CH2:6]1)=[O:4].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:4]

Participants

5

Reactant 2

HCID 58348350HCID 58348350, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58348374HCID 58348374, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-(3-Fluoro-phenyl)-cyclohept-4-enecarboxylic acid methyl ester (Example 12b) (1.09 g) was dissolved in methanol (20 mL), palladium on carbon (50 mg) added and mixture stirred under 4 atm of hydrogen overnight. The solution was filtered and evaporated to afford the sub-titled compound (1.09 g).

Workup

  1. filtrationThe solution was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-fd14663bc65747ad92b50795aaa2952d
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

Loading…