2-bromo-N-(isoxazol-3-yl)acetamide → HCID 44472504, compound

Participants

Reaction Steps

1-(3-Fluoro-phenyl)-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 12d) (50 mg) and 2-bromo-N-isoxazol-3-yl-acetamide (Example 13a) (30 mg) were dissolved in acetonitrile (4 mL) and stirred overnight. The solution was diluted with diethyl ether (12 mL) and stirred overnight. The resulting crystals were filtered off, washed with ether (3×10 mL) and dried to afford the titled compound as a solid (48 mg).

Provenance & Evidence