HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 1-phenylcycloheptanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 1-Phenylcycloheptane-1-carboxylic acid | HCID 28937723 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 1-phenylcycloheptanecarboxylate | HCID 59179615 | — |
Reaction Steps
A 2.0 M solution of trimethylsilyl diazomethane (29.2 mL) was added dropwise to a solution of 1-phenyl-cycloheptanecarboxylic acid (Example 14c) (9.8 g) in methanol (85 mL) and toluene (300 mL) under an atmosphere of nitrogen.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329729B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c84932a33b5e461ca5eb0eb323f73553 |
| Source note | uspto-grants-2012_12 |